Search results for "Ile de France"
showing 8 items of 8 documents
Impaired Binding to Junctophilin-2 and Nanostructural Alteration in CPVT Mutation
2021
Rationale: Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a rare disease, manifested by syncope or sudden death in children or young adults under stress conditions. Mutations in the Ca 2+ release channel/RyR2 (type 2 ryanodine receptor) gene account for about 60% of the identified mutations. Recently, we found and described a mutation in RyR2 N-terminal domain, RyR2 R420Q . Objective: To determine the arrhythmogenic mechanisms of this mutation. Methods and Results: Ventricular tachycardias under stress conditions were observed in both patients with catecholaminergic polymorphic ventricular tachycardia and knock-in mice. During action potential recording (by patch-clamp in …
Analysis of the influence of the PrP genotype on the litter size in Polish sheep using classification trees and logistic regression
2014
The relation between prion protein (PrP) genotype class and litter size was analysed in Polish Merino, Black-headed, Ile de France and Berrichon du Cher sheep in Poland. Litter size was analysed with the classification tree technique and multiple logistic regression for effects of breed, age of ewe, PrP genotype, litter size of ewe at her birth, and at her rearing and year of ewe's birth. The resulting classification tree was 6-level deep and contained 21 leaves. Age, breed and year of birth were more important determinants of litter size than PrP genotype. Importance of PrP genotype in the tree development was 0.560 relative to age of ewe. While the logistic regression analysis showed that…
Changes in the Intra-Metropolitan Location of Producer Services in Ile-de-France (1978-1997) : do information technologies promote a more dispersed s…
2003
Because of their intensive need for face-to-face contacts, producer services have, historically, been found at the core o f CBDs. However, it has been suggested that advances in information technologies could lead to the erosion o f the CBD’s economic base, rendering face-to-face contacts obsolete and enabling producer services to suburbanize. Although a considerable amount o f empirical work has been done on the suburbanization o f these activities in North-America, the same is not true of France. In this paper, we adopt an original methodology to study the role played by face-to-face contacts in the spatial distribution of producer services in the Ile-de-France region between 1978 and 199…
Changes in Spatial and Sectoral Patterns of Employment in Ile-de-France, 1978-97
2006
This paper investigates the spatial distribution of employment in the region of Ile-de-France in 1978 and 1997. Exploratory spatial data analysis is used to identify employment centres and a sectoral analysis of the central business district (CBD) and sub-centres is performed. The results highlight a process of suburbanisation of employment in Ile-de-France between 1978 and 1997. A more polarised space emerges in 1997 than in 1978, with several employment centres specialised in different activities. Moreover, even if the spatial influence of the CBD declines over the study period, the CBD maintains its economic leadership by concentrating a large variety of high-order producer services.
Employment Density in Ile-de-France: Evidence from Local Regressions
2009
In recent decades, cities have experienced a particularly intense phase of urban sprawl. Urban growth has been characterized by the spatial concentration of population in urban areas and the concomitant extension of those urban areas (Nechyba and Walsh 2004). Urban sprawl has also been accompanied by major reorganizations of urban areas with regard to the location choices of households and firms. More specifically, most cities in developed countries have experienced several waves of suburbanization of economic activities: “an economic definition of suburbanization is a reduction in the fraction of a metropolitan area’s population or employment that is located in the central city (correspond…
Les Gaulois d'Ile de France au second Âge du Fer et leur cheptel : état de la question
2002
International audience
La culture en l'île-de-France: toujours une histoire de centralité urbaine
2006
International audience